Medical weight loss fitness journey
Physician-Supervised Protocol

Medical Weight Loss

Transform your body & metabolism with our GLP-1 Optimization Protocol.

The Science of Metabolic Medicine

GLP-1 receptor agonists represent the most significant breakthrough in medical weight loss in decades. These medications work by mimicking incretin hormones that your body naturally produces, targeting the brain's appetite centers and optimizing how your body processes food and stores energy.

At Zen Regenerative Wellness, we combine these cutting-edge pharmaceuticals with comprehensive metabolic monitoring to achieve transformative, sustainable results. Unlike telehealth weight loss clinics, every patient's protocol is designed and supervised by Dr. Kris Shewmake.

Physician-Led

Board-certified oversight

Lab Monitored

Comprehensive bloodwork

Compounded Rx

Custom dosing protocols

Holistic Approach

Peptides + IV + GLP-1

Our Weight Loss Protocols

Physician-selected medications tailored to your metabolic profile — plus a look at where metabolic medicine is heading next

GLP-1 Receptor Agonist

Semaglutide

Ozempic / Wegovy

The gold standard in medical weight loss. Semaglutide mimics GLP-1, a naturally occurring hormone that regulates appetite, slows gastric emptying, and enhances insulin sensitivity. Clinical trials demonstrate an average of 15-17% total body weight loss.

Key Benefits

  • Weekly subcutaneous injection
  • FDA-approved for weight management
  • 15-17% average weight loss in trials
  • Improves cardiovascular risk markers
Dual GIP/GLP-1 Receptor Agonist

Tirzepatide

Mounjaro / Zepbound

The next evolution in metabolic medicine. Tirzepatide activates both GIP and GLP-1 receptors simultaneously, creating a more powerful metabolic response than single-agonist therapies. Patients in the SURMOUNT trial achieved up to 22.5% body weight reduction.

Key Benefits

  • Weekly subcutaneous injection
  • Dual-action: GIP + GLP-1 receptor activation
  • Up to 22.5% weight loss in trials
  • Superior HbA1c reduction vs. semaglutide
In Clinical Trials — For Your Information Only

Retatrutide

The Triple Regulator

The most advanced weight loss molecule in development. Retatrutide activates three metabolic pathways simultaneously — GIP, GLP-1, and glucagon receptors — creating an unprecedented metabolic shift. Phase 2 trials showed up to 24.2% body weight reduction at 48 weeks, with some patients losing over 30%. Retatrutide is still in Phase 3 clinical trials and is not yet FDA-approved — we do not currently offer it, but we share this research so you can see where metabolic medicine is heading, and we are monitoring its progress closely.

Key Benefits

  • Triple-action: GIP + GLP-1 + Glucagon
  • Up to 24.2% weight loss in Phase 2 trials
  • Currently in Phase 3 clinical trials
  • Not yet available — educational information only

Your Weight Loss Journey

How our physician-supervised protocol works

01

Comprehensive Metabolic Assessment

Full bloodwork panel, body composition analysis, metabolic rate testing, and lifestyle evaluation to build your personalized protocol.

02

Physician-Designed Protocol

Dr. Shewmake selects the optimal GLP-1 agonist and dosing strategy based on your unique metabolic profile, medical history, and goals.

03

Weekly Guided Treatment

Subcutaneous injections administered on a precise escalation schedule, with ongoing monitoring of vitals, labs, and metabolic markers.

04

Sustained Results & Optimization

Monthly check-ins to adjust dosing, add complementary therapies (peptides, IV nutrition), and build habits for long-term metabolic health.

Have questions about medical weight loss? Visit our FAQ page