Medical weight loss fitness journey
Physician-Supervised Protocol

Medical Weight Loss

Transform your body & metabolism with our GLP-1 Optimization Protocol.

The Science of Metabolic Medicine

GLP-1 receptor agonists represent the most significant breakthrough in medical weight loss in decades. These medications work by mimicking incretin hormones that your body naturally produces, targeting the brain's appetite centers and optimizing how your body processes food and stores energy.

At Zen Regenerative Wellness, we combine these cutting-edge pharmaceuticals with comprehensive metabolic monitoring to achieve transformative, sustainable results. Unlike telehealth weight loss clinics, every patient's protocol is designed and supervised by Dr. Kris Shewmake.

Physician-Led

Board-certified oversight

Lab Monitored

Comprehensive bloodwork

Compounded Rx

Custom dosing protocols

Holistic Approach

Peptides + IV + GLP-1

Our Weight Loss Protocols

Physician-selected medications tailored to your metabolic profile, from proven single-agonists to the revolutionary triple-action therapies

GLP-1 Receptor Agonist

Semaglutide

Ozempic / Wegovy

The gold standard in medical weight loss. Semaglutide mimics GLP-1, a naturally occurring hormone that regulates appetite, slows gastric emptying, and enhances insulin sensitivity. Clinical trials demonstrate an average of 15-17% total body weight loss.

Key Benefits

  • Weekly subcutaneous injection
  • FDA-approved for weight management
  • 15-17% average weight loss in trials
  • Improves cardiovascular risk markers
Dual GIP/GLP-1 Receptor Agonist

Tirzepatide

Mounjaro / Zepbound

The next evolution in metabolic medicine. Tirzepatide activates both GIP and GLP-1 receptors simultaneously, creating a more powerful metabolic response than single-agonist therapies. Patients in the SURMOUNT trial achieved up to 22.5% body weight reduction.

Key Benefits

  • Weekly subcutaneous injection
  • Dual-action: GIP + GLP-1 receptor activation
  • Up to 22.5% weight loss in trials
  • Superior HbA1c reduction vs. semaglutide
Triple GIP/GLP-1/Glucagon Receptor Agonist

Retatrutide

The Triple Regulator

The most advanced weight loss molecule in development. Retatrutide activates three metabolic pathways simultaneously — GIP, GLP-1, and glucagon receptors — creating an unprecedented metabolic shift. Phase 2 trials showed up to 24.2% body weight reduction at 48 weeks, with some patients losing over 30%.

Key Benefits

  • Triple-action: GIP + GLP-1 + Glucagon
  • Up to 24.2% weight loss in Phase 2 trials
  • Enhanced thermogenesis via glucagon activation
  • Currently in Phase 3 clinical trials

Your Weight Loss Journey

How our physician-supervised protocol works

01

Comprehensive Metabolic Assessment

Full bloodwork panel, body composition analysis, metabolic rate testing, and lifestyle evaluation to build your personalized protocol.

02

Physician-Designed Protocol

Dr. Shewmake selects the optimal GLP-1 agonist and dosing strategy based on your unique metabolic profile, medical history, and goals.

03

Weekly Guided Treatment

Subcutaneous injections administered on a precise escalation schedule, with ongoing monitoring of vitals, labs, and metabolic markers.

04

Sustained Results & Optimization

Monthly check-ins to adjust dosing, add complementary therapies (peptides, IV nutrition), and build habits for long-term metabolic health.

Real Results

Weight Loss Success Stories

Real patients who transformed their metabolic health with physician-supervised GLP-1 protocols at Zen.

DW

David W.

Male, 48 | Business Owner

Concern

Gained 45 lbs over 5 years despite consistent gym attendance. Prediabetic A1C of 5.9. Previous diet attempts failed to produce lasting results. Frustrated and concerned about long-term health.

Zen Protocol

TirzepatideComprehensive LabsIV NutritionNeoLight

Result

Lost 38 lbs in 5 months on physician-supervised tirzepatide. A1C normalized to 5.1. Fasting insulin dropped from 22 to 6. Body composition shifted dramatically — lost visceral fat while preserving lean muscle with concurrent resistance training guidance.

"I've tried everything — keto, intermittent fasting, personal trainers. Nothing stuck. Within 3 weeks on tirzepatide, my relationship with food completely changed. I wasn't fighting cravings anymore. The weight just came off. Dr. Shewmake's monitoring gave me confidence the whole way."

— David W.

38 lbs lost in 5 months

LR

Lauren R.

Female, 39 | Nurse

Concern

Postpartum weight that wouldn't budge — 30 lbs above pre-pregnancy weight 2 years after delivery. Exhausted from night shifts. Emotional eating patterns. Felt "stuck" and defeated.

Zen Protocol

SemaglutidePeptide SupportHormone OptimizationMonthly Labs

Result

Lost 28 lbs over 4 months. More importantly, her energy returned, her mood stabilized (partially due to concurrent hormone optimization showing low progesterone), and she described feeling "like herself again" for the first time since pregnancy.

"I was so skeptical. I thought GLP-1 meds were just a fad. But Dr. Shewmake found that my hormones were tanked on top of the weight issue. Treating both together changed everything. I feel like the person I was before kids — but stronger."

— Lauren R.

28 lbs lost in 4 months

Names have been changed to protect patient privacy. Individual results may vary.

Why Zen Regenerative Wellness

Unlike telehealth weight loss clinics that simply prescribe and forget, Zen provides a comprehensive medical approach. Dr. Kris Shewmake personally oversees every patient's protocol, with regular lab monitoring, body composition tracking, and complementary therapies including peptides, IV nutrition, and metabolic optimization — all under one roof.

01

Comprehensive Metabolic Assessment

Full bloodwork, body composition analysis, and lifestyle evaluation before any prescription is written.

02

Physician-Designed Dosing

Dr. Shewmake selects the optimal GLP-1 agonist and builds a precise titration schedule for your profile.

03

Ongoing Monitoring

Monthly labs, vital tracking, and protocol adjustments — not a set-it-and-forget-it telehealth model.

04

Complementary Therapies

Peptides, IV nutrition, NeoLight, and HBOT stack synergistically with GLP-1 protocols for superior outcomes.

Frequently Asked

Medical Weight Loss Frequently Asked

Common questions about GLP-1 protocols, side effects, and what to expect from a medical weight-loss program.